Low anti oxidants and blue light exposure may lead to AMD

Med Page Today reported, Some cases of age-related macular degeneration (AMD) may arise from a combination of low plasma levels of antioxidants and exposure to blue light from the sun, according to research in the October issue of Archives of Ophthalmology. Researchers studied 4,753 participants older than 65, who all provided blood samples, underwent fundus photography, and answered a dietary questionnaire. Sun exposure was estimated from participants' self-reported information about work, outdoor activities, use of hats, and eyewear (including contact lenses, glasses, and sunglasses). Complete data were available for 101 participants with neovascular age-related macular degeneration, 2,182 participants with early-stage age-related macular degeneration, and 2,117 controls.

Medscape added that the researchers concluded that there was no association between blue light exposure and neovascular AMD or early AMD. In participants in the lowest quartile of antioxidant level (vitamin C, zeaxanthin, vitamin E, and dietary zinc), there were significant associations between blue light exposure and neovascular AMD. Furthermore, odds ratio (OR) was approximately 1.4 for one SD unit increase in blue light exposure, but these ORs for blue light were higher with combined low antioxidant levels, especially vitamin C, zeaxanthin, and vitamin E (OR, 3.7; 95 percent confidence interval [CI], 1.6 - 8.9), which were also associated with early stages of AMD.

The U.K.'s Telegraph notes that AMD, in which the central part of the retina of the eye gradually thins, leaves one in 10 sufferers blind. Lead researcher Astrid Fletcher, Ph.D., of the London School of Hygiene & Tropical Medicine, said, In the absence of cost-effective screening methods to identify people in the population with early AMD, we suggest that recommendations on (eye) protection and diet target the general population, especially middle-aged people

Posted in: AMD, Macular Degeneration, Vitamins