Combined drug to treat nasal and ocular allergies

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A study published in the Annals of Allergy, Asthma, and Immunology and presented at an allergy conference, showed that the combination of azelastine (Astelin or Astepro) and fluticasone propionate (Flonase) gave significantly better nasal symptom relief than placebo or either drug alone.
Azelastine is an antihistamine and mast cell stabilizer that is also sold as eye drops for allergic conjunctivitis under another brand name. Fluticasone is a synthetic glucosteroid that is used as an anti-inflammatory.

Investigators enrolled 610 patients with moderate-to-severe allergic rhinitis, randomly assigning them to get either azelastine, fluticasone, the combination nasal spray, or a placebo nasal spray twice a day for two weeks. They discovered that the combination was significantly better than either drug alone or placebo at relieving nasal symptoms, but the two drugs delivered together -- a combination dubbed MP29-02 -- were not significantly better than either drug as monotherapy for ocular symptoms

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