Tuesday, July 07, 2009

Laser treatment may help reverse effects of dry AMD


A ground-breaking laser treatment may help reverse the effects of age-related macular degeneration (AMD). In early proof-of-concept trials involving about 50 people, the laser technique, which was developed by pioneering eye expert Professor John Marshall of King's College London, appeared to return the back of the eye to its youthful state.

In the technique, a painless 'short pulse' laser boosts the release of the enzymes to clean away natural waste materials, but without damaging the cells that enable vision. The researchers now plan further studies in patients already suffering from AMD in one eye with the aim of saving the sight in their better eye for as long as possible.

Professor Marshall said that he hoped the treatment would be available within two to five years. There is currently no treatment for the most common form of AMD -- known as 'dry' AMD -- which the new laser technique could prevent.

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Monday, July 06, 2009

Recent estimates by the World Health Organization (WHO) calculate at least 171 million people worldwide suffer from diabetes and expect this figure to more than double, to reach 366 million, by 2030

According to Sanofi-Aventis SA, its long-acting Lantus [insulin glargine] drug didn't increase the risk of blindness for diabetics compared to an older type of insulin in a five-year study of more than 1,000 patients. In addition, there was...no 'observable trend' showing a difference in the risk of serious side effects including cancer, the drugmaker said in a statement.

"This 5-year study is the longest randomized controlled study with insulin glargine versus NPH human insulin," said lead investigator Julio Rosenstock, MD, Director of the Dallas Diabetes and Endocrine Center at Medical City and also Clinical Professor of Medicine, University of Texas Southwestern Medical Schoo.

The study results were published in the online edition of the Diabetologia medical journal.
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Lucentis met late-stage trial goal in patients with macular edema due to BRVO

The same view with age-related macular degener...Image via Wikipedia

Genentech, Inc. announced that its macular degeneration drug Lucentis [ranibizumab] met its goal in a late stage trial, improving the vision of patients with macular edema due to branch retinal vein occlusion.

Currently, Lucentis is approved to treat neurovascular, or 'wet,' age-related macular degeneration. Genentech is now trying to get the drug approved for macular edema due to branch retinal vein occlusion, a condition in which the macula, or central part of the retina, swells because fluid leaks or builds up.
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Tuesday, June 30, 2009

Light-sensing worms provide a new tool for the study of vision

A team from the University in Michigan, led by Shawn Xu, has discovered that tiny worms can sense light.

They discovered that the chemical reactions used by the C. elegans ( a 1mm sized worm which is one of the most commonly used model animals in genetic research) are rather similar to the ones in humans. This discovery means that from now on the worm can be used for the research of building blocks of human vision, as well as how disrupting the phototransduction pathway can lead to eye disease.

This discovery may lead to further breakthroughs in the research of vision, helping researchers understand the basis of human vision diseases and promote the understanding of the evolutionary development of eyes in various species.

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Experiment seeks to head off Type 1 diabetes

Researchers at Children's Hospital of Pittsburgh are hoping to control type 1 diabetes by curbing the rogue immune cells that cause it, before patients become completely dependent on daily insulin injections tosurvive.

About 3 million Americans have Type 1 diabetes, where the body mistakenly attacks and destroys cells in the pancreas that produce insulin, the hormone crucial to converting blood sugar to energy.

This novel vaccine -- made from patients' own blood blocks the '911 call' that dendritic cells send to direct T cells to the pancreas. Just altering three communication molecules on their surface basically confuses and paralyzes the T cells. In mice and monkeys, the reprogrammed cells ended the vicious cycle of a pancreas attack that in turn attracts more T cells to attack again.

In human trials, the team has used donated blood to filter out immature dendritic cells and then reprogram them. Animal experiments have shown that after the cells have been re-injected just inside the skin over the pancreas...the cells somehow find their way back to that organ to start working.

Two competing teams - MacroGenics Inc. and Eli Lilly, and Tolerx Inc. and GlaxoSmithKline - have advanced tests under way

Currently, 15 adult diabetics [are] being injected to make sure there are no unexpected side effects before researchers test if reprogrammed cells might really protect children's pancreas cells

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Monday, June 29, 2009

UAW retirees swamping optometry offices in Indiana

A phoropter in use.Image via Wikipedia

The Indianapolis Star reported that, in Indiana, optometry offices have been swamped with United Auto Workers retirees who want to squeeze in one last visit before the coverage evaporates.
According to Bill Matthews, of UAW Local 23, Indiana is home to about 100,000 hourly UAW retirees & all of them have been affected by the change.
The Star described the plight of one retiree who has diabetes and needs regular eye examinations. David Ehman had his eyes checked in the past year, so he cannot make one more covered visit to his optometrist. The last visit he and his wife made to the eye doctor, with coverage, she left with new eyeglasses and he with a fresh set of contact lenses for a combined bill of nearly $800. Now, he said, he will have to shop around. Ehman stated, “The insurance thing really puts a bind on you. You start having to decide, how much is your health worth? “

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Tuesday, June 23, 2009

ವೀಡಿಯೊ ಗೇಮ್ ಟು ಟ್ರೀಟ್ ಲಜ್ಯ್ ಎಯೇ

This image shows many of the characteristics c...Image via Wikipedia

Amblyopia, otherwise known as lazy eye, is a disorder of the visual system that is characterized by poor or indistinct vision in an eye that is otherwise physically normal, or out of proportion to associated structural abnormalities. It has been estimated to affect 1–5% of the population.

Treatment consists of correcting the optical deficit and forcing use of the amblyopic eye, either by patching the good eye, or by instilling topical atropine in the eye with better vision. This, according to the researchers, can lead to social stigma during a formative part of childhood
A review was published recently in Vision Research of a new computer based therapy developed by researchers from Tel Aviv University.

Dr. Uri Polat, Tel Aviv University's eye and brain specialist has developed a computer therapy that could spare kids from the ugly eye patch, letting them enjoy themselves during therapy.
And, this treatment, currently available only for adults, corrects the activity of the neurons in the brain, the main operator of eye function. The study showed that twenty hours in front of Dr. Polat's computer treatment had the same effect as about 500 hours of wearing an eye patch. In this treatment methodology, special and random objects appear, keeping the patient constantly alert and expecting the unexpected.

Researchers from Tel Aviv University have now collaborated with gaming specialists from Rochester University for developing a version of the therapy for kids.
"You see these poor kids in kindergarten wearing the patch. Everyone hates it, especially the parents who know what it's doing to their kid's self-esteem," said Dr. Polat. "As far as I know this is really a one-of-a-kind, non-invasive and effective way to treat lazy eye, without the use of an embarrassing eye patch.
"This is probably the first treatment that attempts to correct lazy eyes in adults, something that doctors had previously given up on. Doctors don't suggest intervention after the age of nine, because it usually doesn't work," he Polat added.



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Monday, June 22, 2009

Human organ and tissue transplantation has become an important and growing part of modern medical practice. Advances in medical technology have resulted in millions of Americans receiving these life-saving or life-enhancing gifts. Eye banks can provide the most precious gifts of the world that is the gift of vision.

N.C. Eye Bank has the distinction of being the provider of most corneas in the world. Eye Bank Association of America reports that the NC based organization provided corneas for 3,440 transplants in 2008; the most of any eye bank in the world.

Eye banks make these transplants possible by processing donated corneas and supplying them to surgeons. According to Bob Russ, the eye bank's director of human resources, the expansion of opportunities to sign up for organ donation is one of the reasons why more people have agreed to be donors.
When a potential donor dies, the eye bank's clock starts ticking.
According to a recent report from Donate Life America people can sign up to be donors through the N.C. Division of Motor Vehicles when getting or renewing their driver's license.
Under the new State Law that passed last year the heart symbol on someone's driver's license is considered binding consent to donate organs, including eye tissue. Before the law was passed, such groups as the eye bank had to get permission from the family to get eye tissue.

How to donate?
• In North Carolina, people can sign up to be organ donors through the N.C. Division of Motor Vehicles. The licenses of those who are donors are marked with a heart.
• Donors should tell their family members about their wishes.
• Corneas to be used in a transplant, must be stored within 24 hours of the donor's death.
• In eye-tissue donations, disease, injury or infection in eyes disqualifies them for transplantation, but they can still be used for education and research purposes.
For more information about eye donation, you may call or visit the N.C.Eye Bank at 765-0932 or go to www.nceyebank.org

Relationship between omega-3 fatty acids, risk of AMD

According to a study published online June 9 in the British Journal of Ophthalmology, the association between omega-3 fatty acids and lower risk of age-related macular degeneration (AMD) appears to be modified by other dietary supplements and disease stage.
For the study, researchers from Tufts University performed an analysis of data from 2,924 patients participating in the Age-Related Eye Disease Study, an eight-year supplementation trial. Dietary intake was assessed using food-frequency questionnaires.
The investigators found that a high intake of the omega-3s docosahexaenoic acid (DHA) and eicosapentaenoic acid...was associated with a lower risk of progression to advanced AMD. The team also found that patients who had low glycemic index diets and high consumption of the omega-3 fatty acids had lower risks of progression to advanced AMD than patients with high intakes alone, but patients in the early stages of AMD...only derived a benefit from consuming large amounts of DHA if they were not taking additional supplementation as part of the study.

Optometric vision therapy described as life-transforming

In an opinion piece in the Los Angeles Times Susan R. Barry, professor of neurobiology in the department of biological sciences at Mount Holyoke College and the author of Fixing My Gaze: A Scientist's Journey Into Seeing in Three Dimensions, writes, Children are still not routinely tested for binocular vision deficits because the standard school vision exam (reading the eye chart with one eye at a time) doesn't screen for defects in eye coordination or stereovision. As a result, many children with vision problems may be labeled learning disabled, or if they misbehave in frustration, diagnosed with attention-deficit hyperactivity disorder.
At age 48, Barry, who suffered from crossed eyes and stereoblindness since childhood, consulted a developmental optometrist who prescribed a program of optometric vision therapy, which taught her how to coordinate her eyes so she could see things in three dimensions. Wishing she had had this therapy as a youngster, she concludes, Detecting these problems early and then seeking proper treatment can improve a child's vision and transform a child's life

Thursday, June 18, 2009

Red Meat Linked To Blindness in Old Age

A new study from Australia suggests that eating lots of red meat is linked to a higher risk of developing age-related macular degeneration (AMD), a leading cause of blindness in old age.

The study was the work of first author Dr Elaine Chong, who is from the Centre for Eye Research Australia based at the University of Melbourne, and colleagues, and is published on 1 April in the advance access issue of the American Journal of Epidemiology.

The results showed that:

* At follow up, 1,680 participants had early stage AMD and 77 had late stage AMD.

* Higher red meat intake was positively associated with early AMD (ie more red meat linked to higher chance of having early AMD).

* The odds ratio for eating meat ten times a week or more versus eating it less than 5 times a week was a significant 1.47 (ie eating meat 10 times a week gave a person 47 per cent higher risk of AMD than if they ate it less than 5 times a week).

* Conversely, eating chicken 3.5 times a week or more was linked to 57 per cent lower risk of late AMD compared to eating it less than 1.5 times a week.

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Blind Man Navigates Obstacle Maze Unaided

Researchers have demonstrated for the first time that people can successfully navigate an obstacle course even after brain damage has left them with no awareness of the ability to see and no activity in the visual cortex, a region of the brain's cortex that is primarily responsible for processing visual inputs.
The findings reported by NY Times published in the December 23rd issue of Current Biology, a Cell Press publication, reveal the importance of alternative routes in the brain, which are active in both those who have suffered severe brain damage to the visual cortex and in all of our everyday lives, according to the researchers.
See a video here
Earlier studies had shown a similar ability in monkeys with comparable brain lesions. The new study was possible only because of the participation of an unusual patient known as TN, who was left blind after selective damage to the visual cortex in both hemispheres of his brain following consecutive strokes.

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Wednesday, June 17, 2009

opical anti-inflammatories may be effective in keratoconus



While the etiology of keratoconus remains unclear, Albert Jun, MD, PhD, reviewed new research indicating that an inflammatory component can be measured in altered concentrations of inflammatory molecules such as IL 6, IL 10, TNF-alpha and matrix metalloproteinases.

This evidence may support the study of topical anti-inflammatory drops for treating and preventing disease advancement, he said at the symposium, which was jointly sponsored by Wilmer Eye Institute and the Maryland Optometric Association.

Homeless, but with clearer vision

My school has always played a significant role in the Boston community. During my training and residency I worked at many of the sites belonging to the New England Eye network.



New England College of Optometry has a program that benefits the homeless and is run by Ceida Chan, OD. This free program offers eye exams administered by students in the third year of the 4 year course as part of their clinical rotation. Many in the homeless community suffer from Diabetes and infectious disease and eye trauma. So this service meets two important needs - in providing medical care and helping in training students to see patients in a 'non clinical' environment, sometimes completing exams with portable equipment.

Boston newspaper covered this here

Experimental stem-cell therapy for blindness

MIT's Technology Review reports that a new treatment for eye disease, developed by Advanced Cell Technology (ACT) uses human embryonic stem cells to re-create retinal pigment epithelium (RPE) cells in the retina that support the photoreceptors needed for vision.

RPE cells are often the first to die off in age-related macular degeneration and other eye diseases, which in turn leads to loss of vision. Now, the experimental therapy has proved safe and effective in animal studies, and may begin early human trials in the next few months if it receives approval from the Food and Drug Administration.

According to Robert Lanza, ACT's chief scientific officer, not only does the RPE treatment avoid the problem of immune rejection, but the cells themselves are relatively easy to create, as embryonic cells tend to spontaneously differentiate into RPE cells and can be easily maintained in that state. ACT plans to focus first on patients with Stargardt's disease, and then move eventually to those with age-related macular degeneration.

TV segment features device designed to restore some vision to the blind

NBC Nightly News reported that a new device offers the enormous promise of restoring sight for those who don't have it. Chief science correspondent Robert Bazell interviewed Kathleen Blake, once totally blind, but now able to see, thanks to a tiny TV camera mounted on her sun glasses that sends images to electrodes placed on the back of her eye.

For 20 years, Dr. Mark Humayun and his team at the University of Southern California (USC) have been working toward the amazing goal of restoring vision to the blind. Not long ago, the USC researchers achieved great improvement in the device, going from 16 electrodes to 60, enabling better sight. According to Bazell, Soon, the glasses will go. Armand Tanguay, an electrical engineer, is developing cameras to be implanted directly in the eye lens in a system many scientists believe will restore better and better sight to millions.

Monday, June 15, 2009

Prevalence of Dry Eye Disease Among US Men

According to a study published in the June issue of the Archives of Ophthalmology, after age 50, approximately 4% of males develop dry-eye disease.
For the study, researchers from Brigham and Women's Hospital analyzed data on 25,444 men, who were asked if they had ever been diagnosed with dry-eye disease and also whether they had symptoms, including dry or irritated eyes. The team found that about three percent reported a previous diagnosis of dry eye, while 6.8 percent said they had constantly or often experienced at least one symptom, such as dryness or irritation. Nearly 2.2 percent reported both symptoms constantly or often. The authors explained that increasing age, high blood pressure, benign prostatic hyperplasia, and the use of antidepressants increase the chances of developing dry-eye disease.

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Tuesday, June 09, 2009

According to a study published in the British Journal of Ophthalmology, people with age-related macular degeneration (AMD) should eat oily fish at least twice a week, because omega-3 fatty acids found in abundance in oily fish appear to slow or even halt the progress of both early and late stage disease.

BBC reports that, for the study, researchers at Tufts University examined data on almost 3,000 people taking part in a trial of vitamins and supplements. The team found that progression to both dry and wet forms of advanced AMD disease was 25 percent less likely among those eating a diet rich in omega-3 fatty acids. In addition, people with advanced AMD who also consumed a low glycemic-index diet and who took supplemental antioxidant vitamins and minerals like vitamin C and zinc appeared to reduce their risk of disease progression by...up to 50 percent. The authors suggested that eating two to three servings of fatty fish...every week would achieve the recommended daily intake (650mg) of omega-3.



Researchers associate intermittent exotropia with mental illness in early adulthood.
MedPage Today reported that, according to a study published in the June issue of Archives of Ophthalmology, children with intermittent exotropia, which is a form of strabismus in which the eyes deviate outward, may have a nearly threefold increased risk of developing mental illness by early adulthood.

For the study, researchers from the Mayo Clinic followed 183 patients who were diagnosed with intermittent exotropia, 118 of whom were female. The cohort, plus age- and sex-matched controls, was followed to a mean age of 21.9 years. The investigators found that overall, a psychiatric disorder, including depression or anxiety, was diagnosed in 97 (53 percent) of the 183 patients, compared with 55 (30.1 percent) of the controls. In fact, children with the ocular problem were 2.7 times more likely to develop a psychiatric disorder than were age- and sex-matched controls, with rates of psychiatric disorders being significantly higher in boys, for reasons that remain unclear, the authors said.

Monday, June 08, 2009

HealthDay reported that, according to a survey conducted by the American Optometric Association (AOA), even though people who wear eyeglasses or contact lenses constitute 81 percent of the population, approximately one of every five of them hasn't seen an eye doctor or eye-care specialist in more than two years, the recommended period between eye checkups. Three of every five of those who don't use corrective lenses said that they had not had a vision exam in more than two years.

Some eye doctors believe this is because most vision problems aren't readily apparent, and because people have enough on their plates. AOA spokesman and optometrist Kerry Beebe, OD, said that the problem with these perceptions is that most eye diseases come on subtly. Once someone recognizes vision loss, it's usually too late to have pursued many avenues of treatment. Dr. Beebe added that people don't realize a lot of eye diseases don't have any symptoms in the early stages, which is where you'd like to treat those kinds of problems.

Wednesday, June 03, 2009

ಸುರ್ಗೆರಿ ಫಾರ್ ರೆದಿಂಗ್ ಗ್ಲಸ್ಸೇಸ್

Pennsylvania's Times Leader reported that with the insertion of the Tecnis multifocal lens, patients with presbyopia, a visual condition that becomes apparent especially in middle age and in which loss of elasticity of the lens of the eye causes defective accommodation and inability to focus sharply for near vision, will regain the ability to see more clearly and not need to rely on reading glasses or bifocals again. Notably, 88 percent of those who received the Tecnis in both eyes reported never wearing glasses four to six months after surgery, and more than 90 percent never needed glasses for distance activities, such as driving, or near activities, such as reading, according to Frank Bucci, MD, who was one of 12 surgeons in the US to use the lens in trial cases with the Food and Drug Administration. The cost of the surgery is about $4,400.
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Tuesday, June 02, 2009

MedPage Today (6/1, Neale) reported that, according to a study published in Ophthalmology, common bacteria found on the eye were susceptible to newer-generation fluoroquinolones. For the study, researchers from Korea's Yonsei University College of Medicine obtained samples from 105 patients using conjunctival swabs immediately before refractive surgery.

Coagulase-negative staphylococci (CNS) were found in 84.9 percent of the cultures; nearly one-third of those (31.4 percent) were methicillin-resistant. Also found were Staphylococcus aureus (2.3 percent), Streptococcus pneumoniae (1.2 percent), and gram-negative bacilli (4.8 percent). Next, the investigators treated the cultures with three newer-generation fluoroquinolones -- gatifloxacin, moxifloxacin, and gemifloxacin -- and two older-generation antibiotics in that class -- ofloxacin and levofloxacin. While the minimum inhibitory concentrations of the antibiotics required to stop the growth of 90 percent of the methicillin-susceptible CNS indicated that all five drugs were effective, the team found that the three newer-generation antibiotics as a group were significantly more effective against methicillin-resistant CNS than the two older ones.

Friday, May 29, 2009

Only 17% of US employers offer vision insurance!

Mississippi's Clarion-Ledger  reports that only 17 percent of US employers report offering vision insurance. They report that  the lack of vision insurance leaves millions...vulnerable to neglecting eye problems. For children, neglected vision problems can lead to poor performance in school. According to the American Optometric Association, children face increasing demands on their visual abilities, noting the size of print in schoolbooks becomes smaller, and the amount of time spent reading and studying increases significantly. Poor vision may also lead to poor work performance, dangerous driving, and diminished quality of life for adults. Experts now estimate that approximately "11 million Americans" may "have untreated refractive errors" which could "easily be corrected to restore perfect, or near-perfect, vision."

Friday, April 24, 2009

Logo of the United States National Eye Institu...Image via Wikipedia

Our eyes are constantly making saccades, or little jumps. Yet the world appears to us as a smooth whole. Somehow, the brain's visual system "knows" where the eyes are about to move and is able to adjust for that movement. In a paper published online this week in Nature, researchers at the University of Pittsburgh and the National Eye Institute (NEI) for the first time provide a circuit-level explanation as to why.

"This is a classic problem in neuroscience," says Marc Sommer, assistant professor of neuroscience at Pitt, who coauthored the paper with Robert Wurtz, senior investigator at NEI, one of the National Institutes of Health. "People have been searching for a circuit to accomplish this stability for the last 50 years, and we think we've made good progress with this study."



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Left ear cochlear implant as worn by userImage via Wikipedia

Australian bionic eye researchers say they are likely to start clinical tests of a bionic eye within two years.

As part of the Government's response to last year's 2020 summit, $50 million will go to bionic eye research.

The director of Bionic Vision Australia, Professor Anthony Burkitt, says an implant is likely to be trialled on patients within two years and commercially available in five years.

"We'd imagine that very much like the development of the Cochlear implant it became better and better over time, so that eventually within five to seven years people would be able to read large print, recognise faces, do that sort of thing," he said.

"So that's the sort of - at least in the initial phase - is the sort of quality of vision that we're looking at."

He says the bionic eye will be initially for people who are completely blind or suffering age-related vision loss.

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Possible cure for macular degeneration

The same view with age-related macular degener...Image via Wikipedia

There is new hope for people who suffer from macular degeneration.

Macular degeneration causes the center of your vision area to blur and deteriorate, but researchers say replacing cells in the filling wall of the retina could cure the condition.

"You're actually giving them a cell. This is a whole entity if you want to call it anything, and that's just a different way of looking at treating people. It truly is regeneration in terms of putting something back that is gone, so it's a major step forward," said Peter Coffey at the University College London.

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Thursday, March 12, 2009

MSNBC reports that, according to Carmen Bunde, program director with Prevent Blindness Nebraska, blurry vision in a child can cause brain damage if the vision is not corrected. In some cases, amblyopia is to blame. It's often called 'lazy eye,' because weak eye muscles make the eye drift to the side, eventually disrupting vision.

Amblyopia is responsible for more vision loss in people age 45 and younger than all other eye disorders combined. The article details how trained volunteers with Prevent Blindness Nebraska screen more than 3,000 low income children a year, many of them...preschool age, for eye disorders. Children who fail the eye exams are sent to their doctors for follow-up care. Approximately one in 20 preschoolers are referred to eye doctors after the screenings. Experts point out that the best time to catch eye disorders is between the ages of three and five years old.

Tuesday, March 03, 2009

Folic acid, B vitamins may reduce AMD risk in some women

Following a USA Today story, Nicholas Bakalar writes in the New York Times Vital Signs column that, according to a study published Feb. 23 in the Archives of Internal Medicine, vitamin B supplements may reduce the risk for age-related macular degeneration (AMD), at least in women with cardiovascular disease or at risk for it.

For the study, researchers from Harvard University followed 5,205 female healthcare professionals with cardiovascular disease or three or more risk factors for it, who were randomly assigned to take either a placebo or a combination of folic acid and vitamins B6 and B12. After about seven years of follow-up, the investigators found 55 cases of AMD in the treatment group, and 82 among those who took a placebo. Specifically, the authors found that those who took the vitamins had a 41 percent reduced risk for significant degeneration, and theorized that the vitamins may reduce blood levels of the amino acid homocysteine, which has been implicated in vision loss.

Wednesday, February 18, 2009

Imaging-analysis technique allows diagnosis of diabetes-related eye problems over the Internet.

Wired News reports that an imaging-analysis technique developed by researchers at the University of Tennessee for finding defects in semiconductors is now being used to diagnose the eye problems associated with diabetes over the Internet. Pictures of the retinas of patients with diabetes are uploaded to a server that compares them to a database of thousands of other images of healthy and diseased eyes.

Algorithms can assign a disease level to the new eye image by looking at the same factors, mainly damage to blood vessels, that an eye doctor would. Currently, more than 25 million Americans suffer from diabetes, which, if left untreated, can cause blindness, among other physical problems. This new technology could help reduce the cost and increase the availability of screening for the eye problems that impair the vision of thousands of patients each year.

Friday, February 13, 2009



Illinois' Belleville News Democrat (2/12) reported that a new device called the Trabectome speeds glaucoma operations and post-surgical recovery.

The device works by reducing pressure in the eye without the need for the filtration or shunts used in traditional glaucoma surgery, allowing surgeons to remove tissue so fluid more easily drains out of the eye. While traditional glaucoma surgery usually means several weeks of recovery with no lifting or bending, the recovery with the Trabectome normally takes about a week. But, not all glaucoma patients...are good candidates for the new device. According to glaucoma researcher Carla J. Siegfried, M.D., patients in the early to moderate stages of the disease are the best candidates

Tuesday, February 10, 2009

Antioxidants & degenerative eye diseases.

According to findings published in the Feb. 2 advance online edition of the Journal of Clinical Investigation, antioxidants may help preserve vision lost in degenerative eye diseases, and a new cell-based gene therapy technique...could eventually offer another option for arresting vision loss from these diseases.
A team from the Scripps Research Institute found that debilitating eye damage in rodents is caused by increased oxidative chemical activity sparked by...new blood vessel growth, rather than simply by the new blood vessel growth itself.
Next, the team was able to identify two remarkably effective treatments. One of these options is simply giving the mice doses of antioxidants orally in order to counterbalance the oxidative damage to neurons, blocking further deterioration in the eyes of treated mice. Then, by using a novel twist to standard gene therapy techniques, the researchers were able to deliver directly to the neurons in question a protein that protects neurons, effectively fortifying them against the onslaught of oxidants.

Spectacle Power adjusted by injecting fluid into the lenses



On its website, BBC News (2/10) reports that a retired Oxford University physics professor has designed adjustable glasses that can be used by people in the developing world. The glasses are altered by injecting tiny quantities of fluid into the lenses, which means that people can have glasses that suit their eyes without the need for a prescription. According to BBC News, the invention should enable millions of people in poorer parts of the world to get glasses for the first time.

Get more info from http://www.adaptive-eyewear.org/home/

Thursday, January 29, 2009

Cataracts are the most common age-related eye disease, with more than 17 percent of Americans age 40 and over affected. The main cause, aside from plain old aging, is exposure to ultraviolet B radiation in sunlight. People can reduce their risk and delay the need for surgery to remove a clouded lens by wearing sunglasses and brimmed hats while outside.

At present, cataract surgery has been refined so that the super small incisions are self-sealing. Besides cataracts, eye conditions such as glaucoma and macular degeneration also affect seniors, although they are more insidious. Typically, medications are used to slow the damage caused by glaucoma. Meanwhile, high doses of supplements, including vitamins C and E and beta carotene and the mineral zinc, have been found to slow the progression of AMD in several trials.

This report was published in the US News and World Report

It was also noted that people with diabetes have added reason to worry: Diabetic retinopathy affects some 40 percent of people with the disease, with 8 percent of all diabetics facing significant vision loss. Keeping your blood sugar levels under control reduces the risk of harm.

Wednesday, January 28, 2009

Glaucoma Associated With Reading Impairments in Elderly

A study by the Johns Hopkins University’s Wilmer Eye Institute found people with glaucoma in both eyes (bilateral) read 29 words per minute slower than those without glaucoma. They also were almost twice as likely to have reading impairment.

Those with glaucoma in one eye (unilateral) had rates about on par with those without the condition, which can cause eye damage and vision loss.

The findings were published in the January issue of Archives of Ophthalmology.

Thursday, January 22, 2009

On the front of its Style section, the Washington Post reports that after losing an eye in a car accident, Tanya Vlach, of San Francisco, CA, wants a new computer eye to replace the natural one she lost. After she put a request for help out on the Internet, Vlach was deluged by tons and tons of responses from hundreds of young techies, some of whom wanted to fit a cell phone camera...into Vlach's beautiful but merely decorative blue acrylic orb.

Vlach settled upon Frank Oliver, 37, whose start-up company, Artisan Robotics, focuses on cutting-edge materials science and power systems for aerospace and military robots. Oliver believes it may take two or three years to develop the eye.

James Weiland, a retinal prosthesis researcher at the University of Southern California's Artificial Retina Project, said the project is not insurmountable, but so many components have to come together that it would be...a challenge.

Tuesday, January 20, 2009

Stem cells to treat corneal blindness

On its website, BBC News reported that researchers at Scotland's Princess Alexandra Eye Pavilion in Edinburgh, working with the Gartnavel General Hospital in Glasgow, will work together using an innovative technique involving adult stem cells to treat patients with corneal blindness. Approximately 20 patients will take part in the initial tests, using cells cultivated before being transplanted onto the surface of the cornea. But, unlike the more controversial embryonic stem-cell research, the technique takes stem cells from dead adult donors. Not long ago, in trials at the University of Pennsylvania, subjects with inherited blindness experienced dramatic improvements in vision after a corrective gene was injected into the eye. The Scottish researchers hope to emulate the success of this previous study.

Friday, January 02, 2009

Choices for Presbyopia Correction



Presbyopia is the slow deterioration of close vision and is most commonly attributed to aging. The condition is caused by a loss of elasticity of the crystalline lens, the structure behind the iris that enables the eye to focus on objects at various distances. People with presbyopia have the choice of correction their vision with reading glasses, monovision contact lenses (one eye is corrected for distance, one for up close), or laser surgery.

In the New York Times SSkin Deep column, Camille Sweeney observed that as the population ages, experts in the eye-care industry say the potential for the presbyopia correction market is huge.

In early trials is a treatment called the transscleral light therapy system, pioneered by a company called Oculatek: in which a laser device emits a low level of light aimed at strengthening the ciliary muscle...under the whites of the eyes. Another option is refractive lens exchange, an outpatient surgical procedure which involves 'replacing the natural crystalline lens with an artificial one'.

Tuesday, December 30, 2008

Scientists working on next generation of artificial retinas

McClatchy reported that researchers at the Doheny Eye Institute at the University of Southern California are testing artificial retinas that they hope can restore partial sight to people who've lost their vision to the most common causes of blindness, retinitis pigmentosa (RP) and macular degeneration.

RP ruins peripheral vision, while macular degeneration causes a blurred or blind spot in central vision. Both conditions irreparably damage the retina, the light-sensitive patch at the back of the eye that converts images into signals and relays them the brain.

Scientists now aim to create sensitive devices that can be implanted in the eye and will let previously blind people recognize faces and read large print. These artificial retinas are still experimental and won't be available for commercial use for years, however. Currently, the Argus Two artificial retina is being tested on 17 blind people in the U.S. and Europe. In the meantime, scientists at the Energy Department's National Laboratories are creating a third-generation artificial retina, and hope to begin human trials in 2011

Tuesday, December 23, 2008

Artificial corneas and retinas



The Miami Herald reports that in developing countries, the need for donor corneas largely exceeds the supply, making the laboratory-developed artificial cornea all the more important.

Researchers from Miami's Bascom Palmer Eye Institute have been at the forefront of its development. Eduardo Alfonso, M.D., interim chair of the institute, explained that doctors prefer donor corneas, because artificial ones are still in the testing phase, though results in the past few years have been good. And, like the human cornea, the synthetic cornea is made in the same curved shape.

Even though artificial corneas are not yet perfect, Alfonso and his team are also starting new projects, including development of an artificial retina and artificial vision technology, in which images processed by the brain would use information that doesn't come from the eyes -- especially useful for those who are completely blind.

Wednesday, December 17, 2008

Tuesday, December 16, 2008

Blind and dream

I have been asked this question before and have struggled to give a rational answer.

In the New York Times Really? column, Anahad O'Connor raised the question of whether people who don't see images during the day might see them when they shut their eyes at night.

According to studies led by a psychologist at the University of Hartford...people born without the ability to see report no visual imagery in their dreams. Instead, they experience a heightening of taste, touch, and smell. They also report a higher percentage of dreams that involve mishaps related to traveling or transportation, perhaps reflecting one of their biggest daytime concerns: safely finding their way around.

Researchers also say that people who go blind before age five rarely experience visual imagery in their dreams. Those who lose their vision after age five, however, often continue to see in their dreams, though the frequency and clarity diminish over time.

In regards to dreams, my favorite quote is by a former President of India, Dr Abjul Kalam “Dreams are not what you see in your sleep, but dreams are that, which do not allow you to sleep”. Fantastic!

Friday, December 12, 2008

Patch versus Drops in treating Lazy eye


In the New York Times Well blog, Tara Parker-Pope wrote that a study published in the Archives of Ophthalmology compares patch therapy for amblyopia with .a weekly regimen of medicated eye drops that essentially work as a patch by blurring vision in the stronger eye.

Mitchell M. Scheiman, O.D., FCOVD, of the Pennsylvania College of Optometry in Philadelphia, (now called Salus University) and colleagues, conducted a randomized study of nearly 200 children, and found that giving the eye drops on the weekend worked about as well as wearing a patch for two hours a day. The eye drops, which contain atropine, work by preventing a muscle in the stronger eye from constricting. As a result, when a child tries to read or focus on something close, the good eye is blurred. The child's weaker eye is forced to focus and work harder, which helps it strengthen over time.

Thursday, December 11, 2008

Diabetes-related eye diseases may skyrocket over next four decades

The New York Times reports that, according to a study published Dec. 9 in the Archives of Ophthalmology, diabetes-related eye diseases will skyrocket over the next four decades, with elderly Hispanics and blacks hit hardest because of higher rates of Type 2 diabetes.

In particular, the report projects that the number of adults 40 and older with diabetic retinopathy -- the leading cause of blindness among working-age adults -- will reach 16 million in 2050, up from 5.5 million in 2005. In addition, the study estimates that the number of diabetics with glaucoma will quadruple to 1.4 million, while the number with cataracts will more than triple to 10 million. Study author Jinan B. Saaddine, M.D., M.P.H., of the Centers for Disease Control and Prevention (CDC), said the findings are a call for to do more to prevent diabetes to start with.

Tuesday, October 28, 2008

Childrens eye exam

A neat video on Fox that describes problems an eye exams detects in children...

Monday, October 27, 2008

news no parent wants to hear!

Optometrist finds no evidence computer use by children leads to myopia.

Canada's Canwest News reports that the Internet abounds with articles allegedly written by eye-care professionals stating that many ophthalmologists believe increased computer use by children puts them at risk for early development of nearsightedness, or myopia.

In fact, these same articles draw little or no difference between myopia, in which far vision is permanently diminished and must be corrected with lenses or laser surgery, and a temporary condition called computer vision syndrome (CVS).

Optometrist Eric DesGroseilliers, O.D., of the Ottawa Optometric Clinic, pointed out that, in over 12 years of practice, during which he has examined the eyes of four to five children a day, he has been unable to attribute any increases in myopia to computer use. Instead, he believes any recent increase in myopia diagnoses is likely because parents are better educated about eye health, and children receive professional eye care earlier. CVS, however, is a temporary discomfort caused by prolonged computer use. Eye strain, headaches, temporary blurred vision, and other complaints make up the symptoms of CVS, but in general they are not considered that serious.

Thursday, October 23, 2008

Medford (OR) Mail Tribune profiles Karen Barlow, a legally blind, independent businesswoman who teaches computer skills to the visually impaired in the Rogue Valley. Barlow's business, Barlow's Computer Training, has contracts with several organizations, including the U.S. Department of Veterans Affairs' Southern Oregon Rehabilitation Center and Clinics.

The Mail Tribune adds, Barlow is one of 50 vendors demonstrating adaptive technologies and other aids to employment at this week's "'Options for Success' conference.

Sponsored by the Office of Vocational Rehabilitation Services, the seminar's theme is "attitudes for success." Advocacy, referral, work-incentive programs and inspirational speeches fill the sessions, which began Tuesday morning.

The goal is to improve the self-esteem and promotional skills of disabled persons eager to join the workforce, said Kristi Hyman of OVRS.

Monday, October 20, 2008

26 percent of Americans have not seen eye-care specialist within past two years.

HealthDay reported that, according to a survey of 1,001 Americans age 18 and older commissioned by the American Optometric Association (AOA), 26 percent of Americans have not visited an eye doctor or eye-care specialist within the past two years, suggesting that many people aren't paying enough attention to their eye health.

AOA expert James Kirchner, O.D., recommended a comprehensive eye exam for adults at least every two years. He emphasized that eye exams are even more important for people who already use corrective lenses,who might just assume they just need a different lens prescription, when they really have a more serious problem. With eye diseases and disorders, as with most health issues, early detection and treatment are often the keys to avoiding permanent problems. For example, the survey showed that 62 percent of respondents didn't know that signs of diabetes may be detected by an eye doctor, while 71 percent didn't know that a comprehensive eye exam can detect hypertension, brain tumors (75 percent), cancer (78 percent), cardiovascular disease (80 percent), and multiple sclerosis (90 percent).

Thursday, October 16, 2008

Painkiller May Prevent Diabetes-Related Retinal Damage

The painkiller pentazocine may help prevent diabetes-related retinal damage that leads to vision loss, according to Medical College of Georgia researchers.

"The effects of this drug on retinal health are phenomenal," Dr. Sylvia Smith, a retinal cell biologist and co-director of the Vision Discovery Institute at MCG's School of Medicine, said in a college news release.

For the study, she compared the retinas of diabetic mice treated with pentazocine and those that didn't receive the drug and found dramatic differences. The findings suggest that the drug and related compounds that bind with the sigma receptor in the eye may help treat the two leading causes of vision loss -- diabetic retinopathy and glaucoma.

The study was published in the September issue of the journal Investigative Ophthalmology & Visual Science.

Wednesday, October 15, 2008

Visual impairment may be more common in people with diabetes

UPI reports that, according to a study published in the Archives ofOphthalmology, visual impairment appears to be more common in people withdiabetes than in those without the disease. Researchers from the Centers forDisease Control and Prevention analyzed data from the National Health andNutrition Examination Surveys from 1999 to 2004, which included 1,237 adultswith diabetes...and 11,767 adults without the disease. The investigators foundthat people with diabetes were more likely to have uncorrectable visionimpairment than those withoutdiabetes.

Tuesday, October 14, 2008

Low anti oxidants and blue light exposure may lead to AMD

Med Page Today reported, Some cases of age-related macular degeneration (AMD) may arise from a combination of low plasma levels of antioxidants and exposure to blue light from the sun, according to research in the October issue of Archives of Ophthalmology. Researchers studied 4,753 participants older than 65, who all provided blood samples, underwent fundus photography, and answered a dietary questionnaire. Sun exposure was estimated from participants' self-reported information about work, outdoor activities, use of hats, and eyewear (including contact lenses, glasses, and sunglasses). Complete data were available for 101 participants with neovascular age-related macular degeneration, 2,182 participants with early-stage age-related macular degeneration, and 2,117 controls.

Medscape added that the researchers concluded that there was no association between blue light exposure and neovascular AMD or early AMD. In participants in the lowest quartile of antioxidant level (vitamin C, zeaxanthin, vitamin E, and dietary zinc), there were significant associations between blue light exposure and neovascular AMD. Furthermore, odds ratio (OR) was approximately 1.4 for one SD unit increase in blue light exposure, but these ORs for blue light were higher with combined low antioxidant levels, especially vitamin C, zeaxanthin, and vitamin E (OR, 3.7; 95 percent confidence interval [CI], 1.6 - 8.9), which were also associated with early stages of AMD.

The U.K.'s Telegraph notes that AMD, in which the central part of the retina of the eye gradually thins, leaves one in 10 sufferers blind. Lead researcher Astrid Fletcher, Ph.D., of the London School of Hygiene & Tropical Medicine, said, In the absence of cost-effective screening methods to identify people in the population with early AMD, we suggest that recommendations on (eye) protection and diet target the general population, especially middle-aged people

Thursday, October 09, 2008

High Priority, Low Coverage

When asked what conditions would most affect their day-to-day living, a majority of Americans rated loss of eyesight as a 10 on a scale of 1 to 10. Paying for vision coverage though has been another story with only 17% of employees offering any kind of vision insurance.

A new report by The Vision Council, Vision Care: Focusing on the Workplace Benefit, examines consumer and business perspectives on vision care and trends in vision care coverage. According to the report, two-thirds of Americans say they would be more willing to get an eye exam if they had some coverage, yet only 17 percent of employers report offering vision insurance. Vision benefits lag behind health and dental benefits, with as many as 44 percent of employers offering dental coverage.

"We know that in today's tough economy everyone is taking another look at their finances," said Ed Greene, chief executive officer for The Vision Council. "As the second most prevalent health condition in the country, vision disorders affect individuals and businesses, making vision coverage an important benefit for both groups."
Vision health is highly valued by most Americans according to the National Eye Institute. When asked what conditions would most affect their day-to-day living, a majority of Americans rated loss of eyesight as a 10 on a scale of 1 to 10.

"Regular eye examinations are an important part of helping Americans maintain their health," said ophthalmologist Elaine G. Hathaway, M.D. "In addition to detecting vision problems and asymptomatic eye disorders, routine eye exams by an eye care professional can detect major health problems such as cardiovascular disease and diabetes," she added.

With 11 million Americans living with an uncorrected vision problem, a number expected to rise as the population ages, the expense to businesses can also be severe. According to the report, the annual financial burden of major adult vision disorders exceeds $35 billion to the U.S. economy, including an estimated $8 billion in lost productivity.
"Uncorrected vision problems are very costly to employers, and it is important for them to recognize that vision health coverage not only maintains a healthy workforce, but has a positive impact on their bottom line," said Greene. For example, studies show that employers gain as much as $7 for every $1 spent on vision coverage.
As with many other benefits, employers are increasingly forced to pass along some of the cost of providing health insurance to employees. Offering vision coverage can help employers enhance their benefits package at a relatively low cost. Such coverage typically costs one-tenth that of medical benefits, and is often utilized more by employees than medical plans.

Sunday, October 05, 2008

Crazy fashion accessory

First it was tattoos, then it was body piercing, but the latest fashion craze looks so painful it's literally eye-watering.
A Dutch designer has come up with a bizarre fashion accessory – eye jewelery that hangs from wire attached to a contact lens.

Eric Klarenbeek has created the eye jewellery that includes items like crystals or flowers.

It hangs beneath the eye, and is fastened to the lens by medical wire. It makes the wearer look as if they are crying.
I feel sad for the models who have to wear these....

Friday, October 03, 2008

Researchers to study depression in AMD patients

Age-related Macular Degeneration (AMD) is the leading cause of vision loss in Americans 60 years of age and older. It gradually destroys sharp, central vision, which is needed for seeing objects clearly and for common daily tasks such as reading and driving. AMD affects the macula, the part of the eye that allows you to see fine detail. In some cases, the disease advances so slowly that people notice little change in their vision. In others, it progresses faster and may lead to a loss of vision in both eyes

Medical News Today reports that researchers at the Farber Institute for Neurosciences at Thomas Jefferson University and the Department of Psychiatry and Human Behavior at Jefferson Medical College of Thomas Jefferson University were recently awarded a $3.7 million grant from The National Eye Institute to study depression in patients diagnosed with age-related macular degeneration.

During the trial, called the Low Vision Depression Prevention Trial, researchers will test a combined treatment to prevent depression and disability associated with AMD. They will also test the efficacy of a low vision rehabilitation and psychological intervention program designed to treat/prevent depression in patients diagnosed with the disease by helping them maintain their independence and participation in enjoyable activities.

Wednesday, October 01, 2008

Apples Benefits for Health & Vision

In a food column in New Hampshire's Telegraph, dietitian Lynda Murray, R.D., writes about the positive effects eating apples may have on overall health.



For example, through the quercetin found in their skin, apples have the unique ability to inhibit the production and release of histamine and other allergic or inflammatory agents. ... Eating an apple a day has been shown to reduce allergic symptoms 46 percent. In addition, the fruit's high flavonoid content...may help protect arteries from harmful plaque buildup. This helps keep cholesterol from oxidizing, and prevents platelets from clumping. Murray recommends that readers eat a diet rich in apples to run a lower incidence of heart disease and stroke. People diagnosed with elevated C-reactive protein and homocysteine probably also face a greater risk of developing age-related macular degeneration (AMD). So, even though an apple isn't the richest source of lutein, combining three or more servings of fruit per day over a period of 12 to 18 years reduces the risk of developing AMD by 30 percent, compared to eating only 1-1/2 servings per day or less, Murray contends.

While there, take note of recipes for Apple Sauce and Apple Crisp

Wednesday, September 24, 2008

Optical Illusions

As a child I have always loved optical illusions. I still am fascinated by the effects they produce. Here is one

New Scientist reported that the cause of the above optical illusion, where the spirals appear to flow, has finally been solved.
This illusion was made famous by a 1981 painting, Isia Leviant's Enigma

Researchers from the Barrow Neurological Institute in Arizona have demonstrated that the way our eyes constantly make tiny movements, called microsaccades, is responsible for the way concentric circles in the painting seem to flow before onlookers' eyes. For the experiment, the investigators had three participants view the painting while cameras recorded their eye movements 500 times every second. Next, the participants were asked to press a button when the speed of the optical 'trickle' of the illusion appeared to slow down or stop, and release it when the trickle seemed faster. The results showed that the illusion became more pronounced when microsaccades were happening at a faster rate. But, when the rate slowed to a stop, the illusion vanished. The authors said that their research may also explain other similar illusions

Tuesday, September 23, 2008

Hurler regains sight after 'miracle' diet supplement

The Irish Independent reported that age-related macular degeneration (AMD) is a condition affecting the central part of the retina at the back of the eye. AMD affects one in 10 people over the age of 50, and is the leading cause of blindness in the Western world.



Dara Kilmartin, consultant ophthalmic surgeon at the Eye and Ear Hospital in Dublin, Ireland, explained that, by 2020, the number of people with AMD is going to at least double, because people are living longer. Dr. Kilmartin said that the risk of AMD becomes greatest over the age of 65. One in five people over 75 will have AMD. Dr. Kilmartin pointed out that risk factors include age, family history, and smoking. In addition, there is a possible link between AMD and obesity, high blood pressure, and high cholesterol. Dr. Kilmartin urged older people to get their eyes tested more often, and to check their 'straight ahead' vision" in each eye separately. The article also discussed the experience of Rosemary Smith, a patient with the wet form of AMD, who is now a peer counselor with the National Council for the Blind of Ireland.

Here is a story of remarkable improvement from Vitamin Therapy

Thursday, September 18, 2008

IOl blocks UV Rays

Intraocular lenses, or IOLs, are the artificial lenses that replace the eye's natural lens that is removed during cataract surgery. IOLs have been around since the 60s, though the FDA gave its approval for one occurred in 1981. Before that, if you had cataracts removed, you had to wear very thick eyeglasses or special contact lenses in order to see afterward, since the natural lens that had been removed wasn't replaced with anything. Traditional IOLs are monofocal, meaning they offer clear vision at distance only, making the need for reading lenses an absolute necessity. New 'multifocal and/or accommodating' IOLs offer the possibility of seeing well at more than one distance, without glasses or contacts.

WHAM-TV Rochester, an ABC affiliate, reported that patients undergoing cataract surgery might want to ask about new replacement lenses that work like heavy duty sunglasses. By blocking ultraviolet (UV) rays and blue light from getting into the eye, the Acry Sof Natural lens filters out potentially damaging rays that can damage the retina in two ways: worsening or creating macular degeneration and tumors or melanoma inside the eye. The new intraocular lens is covered by medical insurance plans.

Tuesday, September 16, 2008

Complementary, alternative medicine becoming more mainstream

I was recently @ the local chapter of Optometrist meeting where the topic of discussion was Complimentary Medicine as applied to Dry Eye and Hormonal Balance. I was very intrigued by what I heard.

On the front page of its Health section, the Washington Post reports that the Johns Hopkins Integrative Medicine and Digestive Center...is the latest indication that alternative medicine is making its mark in mainstream healthcare settings.

This link with Hopkins is part of a trend toward integrating CAM [complementary and alternative medicine] with conventional medicine. A recent survey of 1,400 hospitals found that 27 percent offered some sort of alternative or complementary treatment, which represents a significant increase from eight percent in 1998.

Last year, Hopkins -- a bastion of mainstream medicine -- joined the Consortium of Academic Health Centers for Integrative Medicine. This group of 41 medical centers has pledged to invest in CAM research, and to introduce integrative models of clinical care. The Post notes that the National Institutes of Health will invest about $300 million in CAM research this year.

Monday, September 15, 2008

Boy with low vision plays offensive tackle on youth football team!

California's San Mateo Daily News reported that 10-year-old Tino Benelli, a student who plays offensive tackle as well as defense for the local Pop Warner team, Bayside Broncos, has albinism, a condition that renders him legally blind.

Currently, the boy plays football with low to no vision, because referees do not allow him to wear a doctor-prescribed, tinted face shield, for safety reasons. But, starting next week, he will wear tinted goggles instead. Until then, Tino will play without any light-filtering protection. The Daily News explained that albinism refers to a group of inherited conditions in which people have little or no pigment in their eyes, skin, or hair. They have altered genes that do not make the usual amounts of a pigment called melanin. One in every 17,000 residents in America has some type of albinism. According to the Daily News, people with albinism always have problems with vision, which are not correctable with eyeglasses, and many have low vision.

Wednesday, September 10, 2008

Radiation for Macular Degeneration

One can tel how much time/money and effort is being placed on the problem that's facing the older generation by looking at media exposure and technological advances. Here is another report shown on KGO-TV San Francisco, an ABC affiliate, yesterday.

Macular Degenaration is the most common form of vision loss among people over 60. In a clinical trial taking place in San Jose, Calif., "a combination therapy" is "being tested by Amr Dessouki, M.D. For the trial, Dr. Dessouki will first inject patients' eyes with Lucentis (ranibizumab), a drug approved to treat wet age-related macular degeneration, that is proven to block abnormal blood vessel growth and prevent bleeding. Next, Dr. Dessouki will saturate the cluster of blood vessels with a targeted dose of radiation delivered by "a laser device about the size of a fountain pen. ... The laser radiation is calibrated precisely for the size of the lesion, and administered for a preset amount of time." Should the clinical trial be successful, the combination treatment could free patients from a life of monthly injections!

Implantable capsule may help treat dry macular degeneration

Last week, the U.S. Food and Drug Administration fast-tracked a novel treatment for two eye diseases: age-related macular degeneration (AMD) and retinitis pigmentosa (RP). The new treatment, developed by the Lincoln, RI, biotech company Neurotech, is a capsule that's surgically implanted in the eye.



Inside are genetically engineered cells that produce a protein that may prevent light-sensitive cells in the retina from dying, thus protecting vision. The device is currently in phase II clinical trials. Retinal cells translate light into electrical signals, which are relayed to the brain. But, in both retinitis pigmentosa and in the dry form of age-related macular degeneration, light-sensitive cells in the retina degenerate over time, resulting "in loss of vision."

Currently, RP and dry AMD patients have few or no treatment options. Implanted in the vitreous humor, the device, which is made of a semipermeable plastic, allows ciliary neurotrophic factor (CNTF) protein to diffuse into the retina. In animal studies," CNTF "slowed the degeneration of retinal cells in diseases analogous to RP.

Tuesday, September 09, 2008

Intra Ocular lens


Ohio's Newark Advocate reported that, during cataract surgery, doctors remove the natural lens of the eye and replace it with a new one.



Now, a series of premium lenses allows...more freedom for cataract patients than traditional monofocal lenses. Two multifocal lenses -- ReZoom and ReStor -- have concentric circles with different focusing zones. By comparison, the Crystalens is a homogenous lens that has special arms that allow eye muscles to focus naturally by moving the lens back and forth within the eye.

The Advocate pointed out that each lens has its advantages and drawbacks. For example, rings in the ReStor and ReZoom lenses can cause some patients to experience a halo effect or glare, which should diminish with time. The single lens Crystalens has less glare. The ReStor lens is best for close-up vision; ReZoom and Crystalens are stronger for intermediate and distance vision. A soon-to-be released, new version of Crystalens...is supposed to improve reading vision over its previous design. Despite their advantages, premium lenses are often not covered by insurance, and cost roughly $1,295 per eye, on average.

Eye drops no more

A tiny coil, which is implanted in the eye, could mean an end to the injections and drops used by thousands of patients with common eye complaints.

The spiral-shaped" device, which is inserted through a hollow needle, can be loaded with drugs to treat conditions, such as glaucoma and diabetic macular edema. Called the I-vation, the device is similar to a Slinky toy, and made from a metal alloy. The implant is injected into the eye...in a minimally invasive procedure that takes just 15 minutes.


Medications are mixed into a material which coats the device. Then, as the coating slowly dissolves, they are released over a period of up to two years, medicating the eye continuously.
Here is a comparison of the device with a quarter:

The device's "coiled shape" provides a large surface area available for the drug coating, and also makes it possible to lodge it against the white of the eye, without the need for stitches, and where it can be easily removed and replaced.

High Tech for Low Vision

More than 16 million Americans report some form of visual impairment, even when wearing glasses or contacts. That number is expected to double by 2030 as the aging population brings rising rates of macular degeneration, glaucoma, diabetic retinopathy, and other eye diseases.



For people who suffer from "'low vision' (technically, worse than 20/60 in the better eye), an ever-growing array of devices can help them maximize their remaining vision and, in many cases, compensate for what they've lost. Still, people who are visually impaired should have a comprehensive vision rehab assessment. This includes a visit with an eye doctor, a technology specialist, and an occupational therapist who can evaluate a person's limitations and goals. While Medicare and private insurance will pay for a doctor's evaluation and occupational therapy, most devices generally aren't covered. But, low-vision clinics may be able to get discounts for you, or suggest lower-priced alternatives. Wall Street Journal's Personal Journal section, Melinda Beck lists a number of devices, computer programs, and gadgets designed specifically for people with low vision.

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